TNFB (T861-40N)

TNFB (T861-40N)

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Description : Human active form TNFB (35-205) was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : tored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :  Cell Assay

Endotoxin Level : Less than 0.1 ng/ug (IEU/ug) of TNF-beta.

Molecular Weight : ~18 kDa

Gene Aliases : TNF-B; LT; TNFSF1; LTA

Scientific Background : TNFB is a member of the tumor necrosis factor cytokine family that is primarily expressed on lymphocytes that control lipid metabolism. TNFB is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. TNF-beta acts as a novel therapeutic route for the treatment of dyslipidemia (1). The presence of TNFB accelerates the initiation of immune responses and protects the host from larger viral challenges (2).

References : 
1. Lo, J. C. et.al: Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316: 285-288, 2007.

2. Lund, F. E. et.al: Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza. J. Immun. 169: 5236-5243, 2002.

Product Sheets: (by Lot #):

I123-5.pdf

Research Areas : AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway,