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Description : Mouse active form TNF-beta (34-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : tored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Cell Assay
Endotoxin Level : Less than 0.1 ng/µg (IEU/µg) of TNF-beta.
Molecular Weight : 43 kDa
Gene Aliases : hlb382; LT; LT-alpha; LT-[a]; LTalpha; Ltx; LT[a]; LTA; Tnfb; TNFSF1; Tnfsf1b
Scientific Background : TNF-beta is a member of the tumor necrosis factor cytokine family that are primarily expressed on lymphocytes that control lipid metabolism. TNF-beta is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. TNF-beta acts as a novel therapeutic route for the treatment of dyslipidemia (1). The presence of TNF-beta accelerates the initiation of immune responses and protects the host from larger viral challenges (2).
1. Lo, J. C. et.al: Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316: 285-288, 2007.
2. Lund, F. E. et.al: Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza. J. Immun. 169: 5236-5243, 2002.
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Research Areas : Cancer, Inflammation, NfkB Pathway,