Due to Easter holiday, all delivery service requests will not be processed on Friday, April 10, 2020. Regular delivery schedule will resume on Monday, April 13, 2019.
TIE2 (R849W), Active(T04-12BG)

TIE2 (R849W), Active(T04-12BG)

  • $226.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :Recombinant human TIE2 (R849W) (771-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :771-end (R849W)

Genbank Number :NM_000459

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :~65 kDa

Gene Aliases :TIE-2, TEK, VMCM, VMCM1, CD202B

Scientific Background :TIE2 or TEK is a receptor tyrosine kinase that is expressed principally on vascular endothelium. Disrupting TIE2 function in mice results in embryonic lethality with defects in embryonic vasculature, suggests a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TIE2 receptor tyrosine kinase (1). SHP2 and GRB2 are recruited to the activated TIE 2 kinase domain and are part of the cellular responses that mediate TIE2 function. TIE2 expression is upregulated in the endothelium of vascular "hot spots" in human breast cancer specimens. However, TIE2 is also overexpressed in areas of active angiogenesis in normal tissues (2).

References :
1. Woolf, A S. et al: Angiopoietin growth factors and Tie receptor tyrosine kinases in renal vascular development. Pediatr Nephrol. 2001 Feb;16(2):177-84.

2. Peters, K G. et al: Functional significance of Tie2 signaling in the adult vasculature. Recent Prog Horm Res. 2004;59:51-71.

Product Sheets (By Lot #) :

Y1031-1.pdf

B2013-10.pdf

Research Areas :Angiogenesis, Cancer, Cardiovascular Disease, Inflammation, Neurobiology, Receptor Tyrosine Kinases, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, Angiogenesis, Receptor Tyrosine Kinases