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TGFB3(T833-40CN)

TGFB3(T833-40CN)

  • $204.00


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Description :Human active form TGFB3 (301-412) was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Species :Human

Tag :

Expression System:E.coli

Sequence :301-412

Genbank Number :NP_003230.1

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :Less than 0.1 ng/ug (IEU/ug) of TGF-B.

Molecular Weight :~13.2 kDa

Gene Aliases :ARVD; FLJ16571; TGFB3; TGF-b3

Scientific Background :TGFB3 or transforming growth factor, beta 3 is a member of the TGFβ family of proteins that is a ser/thr protein kinase. TGFB3 is involved in embryogenesis and cell differentiation. TGFB3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development (1). TGFB3 function in normal palate and lung morphogenesis and implicates this cytokine in epithelial-mesenchymal interaction (2).

References :
1. Nawshad, A. et.al: TGF-beta-3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J. Cell Biol. 163: 1291-1301, 2003.

2. Kaartinen, V. et.al: Abnormal lung development and cleft palate in mice lacking TGF-beta-3 indicates defects of epithelial-mesenchymal interaction. Nature Genet. 11: 415-421, 1995.

Formulation :The filter sterilized clear protein solution contains 20% Ethanol and 0.12% Acetic acid.

Product Sheets (By Lot #) :

I123-4.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, WNT Signaling, Cancer, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, WNT Signaling, Cell Cycle, Cellular Stress, Angiogenesis, Ser/Thr Kinases, Cancer