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TGFB1(T831-40N)

TGFB1(T831-40N)

  • $204.00


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Description :Recombinant human TGFB1 (279-end) was expressed in E.coli cells and purified by proprietary chromatographic techniques.

Species :Human

Tag :

Expression System:E.coli

Sequence :279-end

Genbank Number :BC022242

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :Less than 0.1 ng/ug (IEU/ug) of TNF-alpha.

Molecular Weight :~14 kDa

Gene Aliases :CED

Scientific Background :TGFB1 or transforming growth factor, beta 1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. High levels of TGFB1 protein have been localized in developing cartilage, endochondral and membrane bone, and skin and play a key role in the growth and differentiation of these tissues (1). TGFB1 can upregulate gene expression of its own converting enzyme furin in tumor cells, and mutations in TGFB1 gene result in Camurati-Engelmann disease (2).

References :
1. Dickinson, M. E.et.al: Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. Genomics 6: 505-520, 1990.

2. Blanchette, F. et.al: TGF-beta-1 regulates gene expression of its own converting enzyme furin. J. Clin. Invest. 99: 1974-1983, 1997.

Product Sheets (By Lot #) :

F460-4.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, Ser/Thr Kinases, WNT Signaling, Cancer, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, WNT Signaling, Cell Cycle, Cellular Stress, Angiogenesis, Ser/Thr Kinases