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TG003(C57-901)

TG003(C57-901)

  • $105.00


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Description :CLK family Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :719277-26-6

Molecular Formula :C13H15NO2S

Appearance :light yellow powder

Molecular Weight :249.33

Purity :>98% (HPLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (20 mg/ml); or ethanol (15 mg/ml)

Aliases :(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one

Storage and Stability :Store desiccated as supplied at 4oC temperature for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Potent, ATP-competitive inhibitor of Clk-family kinases (IC50s = 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 µM for mClk3)1. Also inhibits DYRK1A/B (IC50s = 24 and 34 nM respectively)2.

References :
1. J Bain M Muraki et al. J. Biol. Chem. 2004 279:24246

2. A Foucourt et al. Molecules 2014 19:15411

3. S A Nishida et al. Nat. Commun. 2011 2:308

Molecular Structure :

Product Sheets (By Lot #) :

D3370-2.pdf

Research Areas :Cancer, Cardiovascular Disease, Cell Cycle, Ser/Thr Kinases