TET3 Protein (T638-31G)
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Description : Recombinant human TET3 (724-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : 724-end
Genbank Number : NM_144993
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~140 kDa
Gene Aliases : hCG_40738
Scientific Background : TET3 or Tet methylcytosine deoxygenase 3 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. TET3 which is a member of the ten-eleven translocation (TET) gene family is involved in myelopoiesis, and defects in TET3 have been associated with several myeloproliferative disorders. TET plays an important role in embryonic stem cell maintenance and inner cell mass cell specification (1). TET3 play an important role in the DNA methylation process (2).
1. Ito, S. et.al: Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333: 1300-1303, 2011.
2. Langemeijer .et al : Acquired mutations in TET3 are common in myelodysplastic syndromes. Nature Genet. 41: 838-842, 2009.
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Research Areas : Cancer, Cell Cycle,