TET2 Protein (T637-31G)

TET2 Protein (T637-31G)

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Description : Recombinant human TET2 (1197-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species : Human

Tag : GST tag

Expression System : Sf9 insect cells using baculovirus

Sequence : 1197-end

Genbank Number : NM_001127208

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Western Blot

Molecular Weight : ~124 kDa

Gene Aliases : Nbla00191, KIAA1546, MDS

Scientific Background : TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine which is involved in myelopoiesis. Defects in TET2 gene have been associated with several myeloproliferative disorders. TET2 play an important role in embryonic stem cell maintenance and inner cell mass cell specification. TET proteins have potential roles in epigenetic regulation through modification of 5mC to 5hmC (1). TET2 enzymatic activity is involved in myeloid tumorigenesis and this could be valuable as a diagnostic and prognostic tool for targeted therapies and to assess responses to anticancer drugs (2).

References : 
1. Tahiliani, M. et.al: Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.Science 324: 930-935, 2009.

2. Ko, M.et.al: Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468: 839-843, 2010.

Product Sheets: (by Lot #):

Q2523-6.pdf

V2553-7.pdf

Research Areas : Cancer, Cell Cycle,