TET1 Protein (T636-31G)
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Description : Recombinant human TET1 (1598-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : 1598-end
Genbank Number : NM_030625
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~110 kDa
Gene Aliases : bA119F7.1; CXXC6; LCX
Scientific Background : TET1 Protein or tet methylcytosine dioxygenase 1 is the original member of a family of methylcytosine dioxygenases that perform several steps required for cytosine demethylation and gene activation (1). TET proteins have potential roles in epigenetic regulation through modification of 5mC to hmC. TET1 plays a main role in modulating DNA methylation levels at CpG-rich promoters and also helps in promoting transcription of pluripotency factors as well as participating in the repression of Polycomb-targeted developmental regulators (2).
1. Ito, S. et.al: Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466: 1129-1133, 2010.
2. Wu, H. et.al: Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 473: 389-393, 2011.
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Research Areas : Cancer, Cell Cycle,