TEC, Active (T03-10CG)

TEC, Active (T03-10CG)

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Description :Full-length recombinant rat TEC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Rat

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :BC166730

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~100 kDa

Gene Aliases :PSCTK4

Scientific Background :TEC is a member of the Tec family of non-receptor protein-tyrosine kinases that are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. TEC is an integral component of T cell signaling and has a distinct role in T cell activation. Defects in TEC may be associated with myelodysplastic syndrome. TEC plays a crucial role in regulating FGF2 secretion under various physiological conditions (1) and it inhibits CD25 expression in rat T-lymphocyte (2).

References :
1. Ebert,A.D.et.al: Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic 11 (6), 813-826 (2010).

2. Susaki,K.et.al: TEC protein tyrosine kinase inhibits CD25 expression in rat T-lymphocytes. Immunol. Lett. 127 (2), 135-142 (2010)

Product Sheets (By Lot #) :

K1661-2.pdf

Research Areas :Angiogenesis, Cancer, Cardiovascular Disease, Inflammation, Neurobiology, Receptor Tyrosine Kinases, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, Angiogenesis, Receptor Tyrosine Kinases