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TDP43 Protein(T74-30G)

TDP43 Protein(T74-30G)

  • $215.00


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Description :Recombinant human TDP43 protein was expressed in E. coli cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:E.coli

Sequence :Full length

Genbank Number :NM_007375

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :72 kDa

Gene Aliases :ALS10; TARDBP

Scientific Background :TAR DNA binding protein (TARDBP) Human was originally discovered in a screen for transcriptional repressors of the transactive response (TAR) DNA binding element of the HIV-1 virus. Contain two RNA-recognition motifs (RRM1 and RRM2), one of which partially overlaps with a putative nuclear export sequence. Mutations in TARDBP were identified in amyotrophic lateral sclerosis (ALS) patients.

References :
1. Ou SH, et al: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J Virol 69:3584–3596. 1995

2. Gitcho MA, et al. TDP-43 A315T mutation in familial motor neuron disease. Ann Neurol 2008 63:535–538. 2008

Product Sheets (By Lot #) :

U1536-5.pdf

L2136-5.pdf

Research Areas :Neurobiology