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Description :Arg Methyl Transferase 1 (PRMT1) Inhibitor
CAS Registry Number :17328-16-4
Molecular Formula :C16H14Cl2N2O4S
Appearance :Brown powder
Molecular Weight :401.3
Purity :>98% (TLC)
Solubilization :May be dissolved in DMSO (50 mg/ml); or ethanol (nil)
Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.
Scientific Background :Selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 uM. Displays no activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells1.
1. EM Bissinger et al. Bioorg. Med. Chem. 2011 19:3717
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology