TC-E 5003(P3695-903)

TC-E 5003(P3695-903)

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Description :Arg Methyl Transferase 1 (PRMT1) Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :17328-16-4

Molecular Formula :C16H14Cl2N2O4S

Appearance :Brown powder

Molecular Weight :401.3

Purity :>98% (TLC)

Solubilization :May be dissolved in DMSO (50 mg/ml); or ethanol (nil)

Aliases :N,N’-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :Selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 uM. Displays no activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells1.

References :
1. EM Bissinger et al. Bioorg. Med. Chem. 2011 19:3717

Molecular Structure :

Product Sheets (By Lot #) :

P3320-37.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology