HOLIDAY SHIPPING UPDATE: All delivery service requests will not be processed on Monday, November 11, 2019 in observance of Remembrance Day. Regular delivery schedule will resume the next business day.
Tau-441 (P301L), Biotinylated (T08-56FBN)

Tau-441 (P301L), Biotinylated (T08-56FBN)

  • $314.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :Recombinant human Tau-441 (P301L) was expressed in E. coli cells. Then the protein was enzymatically biotinylated in vitro.

Species :Human

Expression System:E. coli cells

Sequence :Full length

Genbank Number :P10636-8

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Tau Proteins :Representation of seven Tau proteins, from top to bottom: Tau-441, Tau-410, Tau-412, Tau-381, Tau-383, Tau-352 and Tau-316 (Tau Protein Marker; Cat # T08-07N).

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :64 kDa (45.9 kDa by MW calculation)

Gene Aliases :Tau-F, (N2R4), Tau-4, MAPT, MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549

Scientific Background :Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).

References :
1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.

2. Rial, A. et al: Calcium Dyshomeostasis in beta-Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532.

Product Sheets (By Lot #) :

E3009-10.pdf

Research Areas :Invasion/Metastasis, Neurobiology, p38 Pathway