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Tau-441, GSK3beta-phosphorylated(T08-50FN)

Tau-441, GSK3beta-phosphorylated(T08-50FN)

  • $215.00


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Description :Recombinant human tag-free Tau-441 was co-expressed with GSK3beta in E. coli cells. The Tau-441 protein was phosphorylated by GSK3beta in vivo and in vitro prior to the final chromatography purification.

Species :Human

Tag :tag-free

Expression System:E.coli

Sequence :1-441

Genbank Number :P10636-8

Purity :SDS-PAGE image of purified Tau Proteins. Lane 1, Tau-441, GSK3beta -phosphorylated. Lane 2, Tau-441 Protein, Cat. # T08-54N.

Tau Proteins :Representation of seven Tau proteins, from top to bottom: Tau-441, Tau-410, Tau-412, Tau-381, Tau-383, Tau-352 and Tau-316 (Tau Protein Marker; Cat # T08-07N).

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~64-68 kDa

Gene Aliases :Tau-F, (N2R4), Tau-4, MAPT, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549

Scientific Background :Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, beta-amyloid precursor protein (betaAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).

References :
1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.

2. Rial, A. et al: Calcium Dyshomeostasis in beta-Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532

Product Sheets (By Lot #) :

Y862-3.pdf

Q2558-5.pdf

Q2558-6.pdf

V2277-6.pdf

R2915-8.pdf

Research Areas :Invasion/Metastasis, Neurobiology, p38 Pathway, Neurobiology, p38 Pathway, Invasion/Metastasis