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TAOK1, Active(T24-11G)

TAOK1, Active(T24-11G)

  • $226.00


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Description :Recombinant human TAOK1 (1-314) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-314

Genbank Number :NM_020791

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~63 kDa

Gene Aliases :PSK2, MARKK, MAP3K16, FLJ14314, KIAA1361

Scientific Background : TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs) (1). The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway. A microtubule affinity-regulating kinase kinase, TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay (2).

References :
1. Hutchison, M. et al: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 1998; 273(44):28625-32.

2. Draviam, V.M. et al: A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat. Cell Biol. 2007; 9(5):556-64.

Product Sheets (By Lot #) :

G370-1.pdf

W3026-7.pdf

Research Areas :Cancer, Inflammation, p38 Pathway, JNK/SAPK Pathway, Invasion/Metastasis, Ser/Thr Kinases, Cancer, Inflammation, p38 Pathway, JNK/SAPK Pathway, Invasion/Metastasis, Ser/Thr Kinases