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TAK1-TAB1, Active(M15-13G)

TAK1-TAB1, Active(M15-13G)

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Description :Recombinant human proteins TAK1 (1-303) and TAB1 (437-end), linked by a small peptide (DFGGGGG), were expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :TAK1 (1-303) and TAB1 (437-end)), linked by a small peptide (DFGGGGG)

Genbank Number :NM_003188

Genbank Number 2 :NM_006116

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Scientific Background :TAK1 is a serine/threonine protein kinase that mediates signaling by TGFβ and morphogenetic protein (BMP) (1). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (NfκB). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8 (2). Thymocytes lacking TAK1 fail to activate NfκB and JNK and are prone to apoptosis upon stimulation.

Molecular Weight :~74 kDa

Gene Aliases :TAK1: MAP3K7, TGF1a; TAB1: MAP3K7IP1, 3'-Tab1, MGC57664

Applications :Kinase Assay, Western Blot

Storage, Stability and Shipping :Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

References :
1.Yamaguchi, K. et al: Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270: 2008-2011, 1995.

2.Liu, H.-H. et al: Essential role of TAK1 in thymocyte development and activation. Proc. Nat. Acad. Sci. 103: 11677-11682, 2006.

Product Sheets (By Lot #) :

T1064-3.pdf

I3036-7.pdf

Research Areas :Cancer, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, WNT Signaling, Cell Cycle, Cellular Stress, Angiogenesis, Ser/Thr Kinases, Cancer, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, WNT Signaling, Cell Cycle, Cellular Stress, Angiogenesis, Ser/Thr Kinases