Anti-Trail(T880-63R)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the TRAIL protein
Cited Applications :WB, ELISA, IHC
Cross Reactivity :Human
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :TRAIL antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human TRAIL.
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of Trail in HeLa cell lysate containing 10, 2.5, or 1 ng of recombinant protein containing extracellular domain of Trail with Trail antibody at 1 ug/ml.
Sample Data :Immunohistochemistry of Trail in human brain tissue with Trail antibody at 20 ug/ml.
Scientific Background :Trail or TNF-related apoptosis inducingg ligand is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family which function as prominent mediators of immune regulation and the inflammatory response. TRAIL induces significant cell death in human colon polyps and providing a potentially selective approach for colorectal cancer chemoprevention by targeting APC-deficient cells for apoptosis (1). TRAIL plays a crucial role in hepatic cell death and hepatic inflammation (2).
References :
1. Zhang, L.. et.al: Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature 464: 1058-1061, 2010.
2. Zheng, S.-J. et.al: Critical roles of TRAIL in hepatic cell death and hepatic inflammation. J. Clin. Invest. 113: 58-64, 2004.
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Research Areas :AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Cancer, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, PKA/PKC Pathway, Apoptosis/Autophagy