TTBK2, Active(T18-11G)
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Description :Recombinant mouse TTBK2 (70-538) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Mouse
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :70-538
Genbank Number :NM_080788
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~88 kDa
Gene Aliases :mKIAA0847; TTBK; TTBK1; TTK
Scientific Background :TTBK2 or tau tubulin kinase 2 is a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. TTBK2 is a member of the casein kinase (CK1) group of eukaryotic protein kinases that is involved in tau phosphorylation and aggregation (1). Mutations in TTBK2 cause spinocerebellar ataxia type 11 (SCA11) (a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem) (2).
References :
1. Sato, S. et: Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J. Neurochem. 98: 1573-1584, 2006.
2. Houlden, H. et.al: Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nature Genet. 39: 1434-1436, 2007.
Product Sheets (By Lot #) :
Research Areas :Invasion/Metastasis, Neurobiology, p38 Pathway, Ser/Thr Kinases, Neurobiology, p38 Pathway, Invasion/Metastasis, Ser/Thr Kinases