Tau Antibody(T08-62R)
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Description :Rabbit Polyclonal Antibody
Genbank Number :NM_020630
Cited Applications :WB (1:1000); IHC; ELISA
Ideal working dilutions for each application should be empirically determined by the investigator.
Specificity :Detects ~45.8 kDa.
Cross Reactivity :Human, Mouse
Host :Rabbit
Immunogen :Recombinant Human Tau 2NR4 P301S Fibril
Formulation :PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
Stability :1yr at –200C from date of shipment. Avoid freeze/thaw cycle.
Scientific Background :Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
References :1. www.alz.org/alzheimers-dementia/facts-figures
2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907)
3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497.
4. Goedert, M. and Spillantini, M. G. (2017). Mol Brain. 10:18.
5. Guo, J. and Lee, M.Y. (2013). FEBS Lett. 587(6): 717-723.
6. Alberici, A. et al. (2004). J Neurol Neurosurg Psychiatry. 75:1607-1610.
Sample Data :Western Blot Analysis of SH-SY5Y showing detection of ~45.8 kDa Tau protein using Rabbit Tau Polyclonal Antibody (Cat# T08-62R). Lane 1: Molecular Weight Ladder (MW). Lane 2: SH-SY5Y. Predicted/Observed Size: ~45.8 kDa. Other Band(s): 50 kDa, 65 kDa. 
Sample Data :Immunohistochemistry analysis using Rabbit Tau Polyclonal Antibody (Cat# T08-62R). Tissue: Kidney. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary antibody: Rabbit Tau Polyclonal Antibody (Cat# T08-62R). 
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