Anti-phospho-Tau (Ser404)(T08-365HR)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes endogenous levels of Tau only when phosphorylated at serine 404
Cited Applications :WB
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 404 (D-T-SP-P-R)
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of extract from mouse brain tissue using a pan-Tau antibody (Lanes A and B) and Anti-phospho-Tau (Ser404) antibody (Lanes C and D)
References :
1. Li G, et al: Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. J Biol Chem. 2004 Apr 16;279(16):15938-45.
2. Noble W, et al: Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. 2003 May 22;38(4):555-65.
3. Giasson BI, et al: The environmental toxin arsenite induces tau hyperphosphorylation. Biochemistry. 2002 Dec 24;41(51):15376-87.
4. Lee G, et al: The microtubule binding domain of tau protein. Neuron. 1989 Jun;2(6):1615-24. 5. Andreadis A et al: Structure and novel exons of the human tau gene. Biochemistry. 1992 Nov 3;31(43):10626-33.
Product Sheets (By Lot #) :
Research Areas :Invasion/Metastasis, Neurobiology, p38 Pathway, Neurobiology, p38 Pathway, Invasion/Metastasis