Anti-phospho-Tau (Ser214)(T08-365GR)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes endogenous levels of Tau only when phosphorylated at serine 214
Cited Applications :WB
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 235 (P-K-SP-P-S)
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of extract from mouse brain tissue using Anti-phospho-Tau (Ser214) antibody
References :
1. Smet C, et al: Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein. FEBS Lett. 2005 Aug 1;579(19):4159-64.
2.Puig B, et al: Individual and regional variations of phospho-tau species in progressive supranuclear palsy. Acta Neuropathol. 2005 Sep;110(3):261-8.
3. Götz J, et al: Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001 Aug 24;293(5534):1491-5.
4. Illenberger S, et al: The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. Mol Biol Cell. 1998 Jun;9(6):1495-512.
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Research Areas :Invasion/Metastasis, Neurobiology, p38 Pathway, Neurobiology, p38 Pathway, Invasion/Metastasis