Anti-phospho-Tau (Ser235)(T08-365FR)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes endogenous levels of Tau only when phosphorylated at serine 235
Cited Applications :WB
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 235 (P-K-SP-P-S)
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of extract from mouse brain tissue using Anti-phospho-Tau (Ser235) antibody
References :
1. Alonso Adel C, et al: Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. J Biol Chem. 2004 Aug 13;279(33):34873-81.
2. Liu F, et al: Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. FEBS Lett. 2002 Oct 23;530(1-3):209-14.
3. Sengupta A, et al: Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. Arch Biochem Biophys. 1998 Sep 15;357(2):299-309.
4. Kyriakis JM, et al: The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 1994 May 12;369(6476):156-60.
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Research Areas :Invasion/Metastasis, Neurobiology, p38 Pathway, Neurobiology, p38 Pathway, Invasion/Metastasis