Anti-phospho-Tau (Ser396)(T08-365ER)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes endogenous levels of Tau only when phosphorylated at serine 396
Cited Applications :WB
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 396 (Y-K-SP-P-V)
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of extract from mouse brain tissue using a pan-Tau antibody (Lanes A and B) and Anti-phospho-Tau (Ser396) antibody (Lanes C and D)
References :
1. Puig B, et al: Individual and regional variations of phospho-tau species in progressive supranuclear palsy. Acta Neuropathol. 2005 Sep;110(3):261-8.
2. DeGiorgis JA, et al: Phosphoproteomic analysis of synaptosomes from human cerebral cortex. J Proteome Res. 2005 Mar-Apr;4(2):306-15.
3. Alonso Adel C, et al: Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. J Biol Chem. 2004 Aug 13;279(33):34873-81.
4. Kyriakis JM, et al: The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 1994 May 12;369(6476):156-60.
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Research Areas :Invasion/Metastasis, Neurobiology, p38 Pathway, Neurobiology, p38 Pathway, Invasion/Metastasis