Anti-phospho-Tau (Thr205)(T08-365BR)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the Tau protein phosphorylated at threonine 205
Cited Applications :WB
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr205
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of extracts mouse brain using Tau antibody (lanes 1 and 2) and anti-phospho-Tau (Thr205) antibody (lanes 3 and 4).
Scientific Background :The Tau family of proteins interacts directly with microtubules to stabilize macromolecular structures. Microtubule association is dependent on the phosphorylation state of Tau proteins (1). Hyperphosphorylated Tau proteins are implicated in Alzheimer's disease (AD) where it is a major component of the offending protein aggregates. Other components of the aggregates include misfolded proteins such as beta-amyloid precursor protein (betaAPP), ubiquitin, and various chaperones and protein kinases. Malfunctioning Tau proteins are associated with microtubule disintegration and collapse of the neuronal transport system (2).
References :
1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.
2. Rial, A. et al: Calcium Dyshomeostasis in beta-amyloid and tau-bearing skeletal myotubes. J. Biol. Chem., 2004; 279: 3524-53532.
Product Sheets (By Lot #) :
Research Areas :Invasion/Metastasis, Neurobiology, p38 Pathway, Neurobiology, p38 Pathway, Invasion/Metastasis