TGFBR2, Active(T08-11BG)
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Description :Recombinant mouse TGFBR2 (215-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Mouse
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :215-end
Genbank Number :BC052629
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~69 kDa
Gene Aliases :1110020H15Rik; AU042018; DNIIR; RIIDN; TbetaR-II; TbetaRII; TBR-II
Formulation :50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Scientific Background :TGFBR2 is a member of the TGFbeta receptor subfamily and is a ser/thr protein kinase. TGFBR2-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses (1). The TGFBR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-beta type II receptor. Mutations in TGFBR2 gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors (2).
References :
1. Cheng, N. et al. Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis." Cancer Res. 2007;67(10):4869-77.
2. Sakai, H. et al. Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes. Am. J. Med. Genet. 2006; 140(16):1719-25.
Product Sheets (By Lot #) :
Research Areas :AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, Ser/Thr Kinases, Cancer, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, WNT Signaling, Cell Cycle, Cellular Stress, Angiogenesis, Ser/Thr Kinases