TEC, Active(T03-10G)
FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Full-length recombinant human TEC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_003215
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~103 kDa
Gene Aliases :PSCTK4, MGC126760, MGC126762
Scientific Background :TEC is a member of the Tec family of non-receptor protein-tyrosine kinases that are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. TEC is an integral component of T cell signaling and has a distinct role in T cell activation. Defects in TEC may be associated with myelodysplastic syndrome. TEC plays a crucial role in regulating FGF2 secretion under various physiological conditions (1) and it inhibits CD25 expression in human T-lymphocyte (2).
References :
1. Ebert,A.D.et.al: Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic 11 (6), 813-826 (2010).
2. Susaki,K.et.al: TEC protein tyrosine kinase inhibits CD25 expression in human T-lymphocytes. Immunol. Lett. 127 (2), 135-142 (2010)
Product Sheets (By Lot #) :
Research Areas :Angiogenesis, Cancer, Cardiovascular Disease, Inflammation, Receptor Tyrosine Kinases, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, Angiogenesis, Receptor Tyrosine Kinases