SYVN1 (HRD1) Protein(S284-31G)

SYVN1 (HRD1) Protein(S284-31G)

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Description :Recombinant human SYVN1 (HRD1) (226-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :226-end

Genbank Number :NM_172230

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~80 kDa

Gene Aliases :SYVN1 (synoviolin); HRD1; DER3

Scientific Background :Synoviolin (SYVN1/HRD1) is a multispanning membrane protein with its C-terminal RING-H2 finger domain located in the cytoplasm. A member of the E3 ubiquitin-protein ligase family that accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, acting as a part of the ER-associated degradation (ERAD) system involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.

References :
1. Nadav E, et al: A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochem Biophys Res Commun. 2003 303(1):91-7.

2. Kikkert M, et al: Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J Biol Chem. 2004 279(5):3525-34.

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Research Areas :Cancer, Cellular Stress, Inflammation, Neurobiology