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SYK, Active(S52-10G)

SYK, Active(S52-10G)

  • $226.00


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Description :Recombinant full-length human SYK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_003177

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~100kDa

Scientific Background :SYK is a non-receptor protein tyrosine kinase that is widely expressed in hematopoietic cells. It is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. In B cells, SYK plays a crucial role in intracellular signal transduction induced by oxidative stress as well as antigen receptor engagement (1). SYK has been shown to act as a potential tumor suppressor in breast cancer. Absence of SYK protein in primary breast tumors is correlated with poor outcomes. SYK deficient cells have increased motility that is restored to normalcy by replacement with wild-type SYK (2).

References :
1. Takano, T. et al: Role of protein-tyrosine kinase syk in oxidative stress signaling in B cells. Antioxid Redox Signal. 2002 Jun;4(3):533-41.

2. Navara, C S.: The spleen tyrosine kinase (Syk) in human disease, implications for design of tyrosine kinase inhibitor based therapy. Curr Pharm Des. 2004;10(15):1739-44.

Product Sheets (By Lot #) :

C368-1.pdf

V311-1.pdf

N007-1.pdf

K1598-2.pdf

K1562-3.pdf

Research Areas :Cancer, Inflammation, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, Cellular Stress, Cytoplasmic Tyrosine Kinases, Cancer, Inflammation, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, Cellular Stress, Cytoplasmic Tyrosine Kinases