Sunitinib malate(F11-900G)

Sunitinib malate(F11-900G)

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Description :VEGFR, PDGFR inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :341031-54-7

Molecular Formula :C22H27FN4O2 ∙ C4H6O5

Appearance :Orange solid

Melting Point :N/A

Molecular Weight :532.6

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (13 mg/ml, warm)

Aliases :
1. N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malate

2. SU-11248

Storage and Stability :Storage, Stability and Shipping

Scientific Background :A potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRbeta and Kit (Ki = 2-17 nM) (1). Also inhibits cFMS (IC50=7 nM) (2) and FLT3 (3). Potent inhibitor of angiogenesis (4). Clinically useful anticancer agent. Cell permeable.

References :
1. ED Deeks et al. Drugs 2006 66:2255

2. J Guo et al. Mol. Cancer. Ther. 2006 5:1007

3. AM O’Farrell et al. Blood. 2003 101:3597

4. R Roskoski et al. Biochem. Biophys. Res. Commun. 2007 356:323

Molecular Structure :

Product Sheets (By Lot #) :

T2257-20.pdf

Research Areas :AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases, Cancer, Neurobiology, Cell Cycle, Angiogenesis