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SU-4312(F11-900F)

SU-4312(F11-900F)

  • $83.00


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Description :VEGFR, PDGFR inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :5812-07-7

Molecular Formula :C17H16N2O

Appearance :Orange powder

Melting Point :N/A

Molecular Weight :264.3

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved DMSO (25 mg/ml)

Aliases :
1. 3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-one

2. DMBI

Storage and Stability :Storage, Stability and Shipping

Scientific Background :Potent and selective inhibitor of VEGF receptor tyrosine kinase (Flk-1, KDR). Inhibits unactivated kinase 100-fold greater (IC50=0.04 uM) than activated kinase (IC50=4.0 uM ) (1). Weak inhibitor of PDGF receptor tyrosine kinase (IC50=19.4 uM) (2). Inhibits endothelial cell activation and angiogenesis in a mouse model of Alzheimers disease (3).

References :
1. RL Kendall et al. J. Biol. Chem. 1999 274:6453

2. L Sun et al. J. Med. Chem. 1998 41:2588

3. Schultheiss et al. Angiogenesis 2006 9:59

Molecular Structure :

Product Sheets (By Lot #) :

T2257-8.pdf

Research Areas :Cancer, Neurobiology, Cell Cycle, Angiogenesis