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STRN-ALK (Sex3Aex20), Active (A19-19JG)

STRN-ALK (Sex3Aex20), Active (A19-19JG)

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Description :Recombinant human fusion STRN (1-137a.a., exons1-3) - ALK (1058a.a.-end, exons20-29) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :STRN (1-137a.a., exons1-3) - ALK (1058a.a.-end, exons20-29)

Genbank Number 1:NM_003162

Genbank Number 2 :NM_004304

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :110 kDa

Gene Aliases :STRN: PPP2R6A; SG2NA; STRN1
ALK: ALK (Ki-1), CD246

Scientific Background :Anaplastic large cell lymphomas are associated with chromosomal aberrations involving the anaplastic lymphoma kinase (ALK) gene, resulting in the expression of novel chimeric ALK proteins with transforming properties. Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types (1). A fusion protein of STRN-ALK has been reported in a non-small cell lung cacner due to resistant to Alectinib (2).

References :
1. Palmer R H, et al: Anaplastic lymphoma kinase: signalling in development and disease. Biochem J. 2009 May 27;420(3):345-61.

2. Nakanishi Y, et al: Case Report of Non-Small Cell Lung Cancer with STRN-ALK Translocation: A Nonresponder to Alectinib. J Thorac Oncol. 2017 Dec;12(12):e202-e204.

Product Sheets (By Lot #) :

W3112-8.pdf

Research Areas :Cancer