STO-609(C17-900)

STO-609(C17-900)

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Description :CAMKK inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :52029-86-4

Molecular Formula :C19H10N2O3 ∙ CH3COOH

Appearance :Yellow powder

Melting Point :N/A

Molecular Weight :314.3

Purity :98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in: DMSO (10 mg/ml)

Aliases :7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

Scientific Background :Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKalpha and CaM-KKbeta respectively). Binds to the ATP-binding site. Displays >80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Cell permeable.

References :
1. H Tokumitsu et al. J. Biol. Chem. 2002 277:15813

2. H Tokumitsu et al. J. Biol. Chem. 2003 278:10908

Molecular Structure :

Product Sheets (By Lot #) :

T2257-16.pdf

Research Areas :Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Ser/Thr Kinases