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STK36, Active(S48-11G)

STK36, Active(S48-11G)

  • $226.00


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Description :Recombinant human STK36 (1-457) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-457

Genbank Number :BC026158

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~87 kDa

Gene Aliases :FU, DKFZp434N0223

Scientific Background :STK36 is a member of the serine/threonine kinase family and is similar to a protein which plays a key role in the Hedgehog signaling pathway. STK36 is a positive regulator of the GLI zinc-finger transcription factors and controls the activity of GLI1 and GLI2 by opposing the effect of SUFU (1). STK36 is highly expressed in fetal lung and adult testis (2). STK36 is a target for the treatment of gastrointestinal cancers since the Hedgehog signaling pathway is frequently activated in certain kinds of gastrointestinal cancers. Defects in the STK36 gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia.

References :
1. Murone, M. et.al: Gli regulation by the opposing activities of Fused and Suppressor of Fused. Nature Cell Biol. 2: 310-3112, 2000.

2. Nagase, T. et.al: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 337-345, 1999.

Product Sheets (By Lot #) :

F554-3.pdf

Research Areas :Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Ser/Thr Kinases