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STK3, Active(S24-10G)

STK3, Active(S24-10G)

  • $226.00


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Description :Recombinant full-length human STK3 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :BC010640

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~87 kDa

Gene Aliases :KRS1; MST2; FLJ90748

Scientific Background :STK3, also known as MST2, encodes a protein of 491-amino acid which contains an N-terminal catalytic domain characteristic of STKs (1). STK3 and STK4 share 94% amino acid identity in the catalytic domain and 78% identity overall. RAF1 has been shown to counteract apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2). STK3 is a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (2). STK3 activation presumably allows cells to resist unfavorable environmental conditions.

References :
1. Creasy, C L. et al: Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 167: 303-306, 1995.

2. Lee, K K. et al: MST, a physiological caspase substrate, higly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276: 19276-19285, 2001.

Product Sheets (By Lot #) :

K349-1.pdf

I145-3.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Cardiovascular Disease, AKT/PKB Pathway, JNK/SAPK Pathway, Apoptosis/Autophagy, Ser/Thr Kinases, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, AKT/PKB Pathway, JNK/SAPK Pathway, Apoptosis/Autophagy, Ser/Thr Kinases