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STAT5B Protein(S56-54BH)

STAT5B Protein(S56-54BH)

  • $215.00


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Description :Recombinant full-length human STAT5B was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.

Species :Human

Tag :His tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :BC065227

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~95 kDa

Gene Aliases :STAT5

Scientific Background :STAT5B or signal transducer and activator of transcription 5B is a member of the STAT family of transcription factors. STATs are phosphorylated by the receptor associated kinases and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5B is activated in response to a variety of cytokines (1). The JAK/STAT pathway mediates a key signal from the somatic gonad that regulates male germline sexual development (2). STAT5B is critical for maintenance of tolerance in vivo and it is proposed that STAT5B is probably activated by IL2R.

References :
1. Wang, D.et.al: Naturally occurring dominant negative variants of Stat5.Molec. Cell Biol. 16: 6141-6148, 1996.

2. Wawersik, M.et.al: Somatic control of germline sexual development is mediated by the JAK/STAT pathway. (Letter) Nature 436: 563-567, 2005.

Product Sheets (By Lot #) :

U1559-5.pdf

Research Areas :Inflammation, ERK/MAPK Pathway, Cancer, JAK/STAT Pathway, Apoptosis/Autophagy