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SRPK1, Active(S21-10G)

SRPK1, Active(S21-10G)

  • $226.00


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Description :Recombinant full-length human SRPK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :BC038292

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~130 kDa

Gene Aliases :SFRSK1

Scientific Background :SRPK1 is a Ser/Thr protein kinase that has sequence and function similar to SRPK2. In human cancer cells, it was observed that inactivation of SRPK1 induces cellular resistance to anticancer drugs such as cisplatin and bleomycin (1). SRPK1 phosphorylates serine/arginine-rich (SR) proteins, such as splicing factors ASF/SF2, SC35, and SRp55, in their arginine/serine-rich (RS) domains in vitro. Hence it is believed that SRPK1 plays a key role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors (2).

References :
1. Hayes, G.M. et al: Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas. Cancer Res. 2007;67(5):2072-80.

2. Gui, J.-F. et al: A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature 369: 678-682, 1994.

Product Sheets (By Lot #) :

L243-3.pdf

S192-1.pdf

I3298-12.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Ser/Thr Kinases, Cancer, Neurobiology, Inflammation, Ser/Thr Kinases