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SRPIN340(S21-901)

SRPIN340(S21-901)

  • $83.00


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Description :SRPK inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :218156-96-8

Molecular Formula :C18H18F3N3O

Appearance :White powder

Molecular Weight :349.4

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (40 mg/ml) or ethanol (25 mg/ml)

Aliases :N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

Storage and Stability :Store desiccated as supplied at -20oC temperature for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :Serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 µM)1. Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases.

References :
1. T Fukuhara et al. Proc. Natl. Acad. Sci. USA 2006 103:11329

2. MV Gammons et al. Invest. Ophthalmol. Vis. Sci. 2013 54:5797

3. MV Gammons et al. Br. J. Cancer 2014 111:477

Molecular Structure :

Product Sheets (By Lot #) :

D3370-10.pdf

Research Areas :Cancer, Inflammation, Neurobiology, Ser/Thr Kinases