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SRMS, Active(S20-11G)

SRMS, Active(S20-11G)

  • $226.00


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Description :Recombinant human SRMS (215-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :215-end

Genbank Number :NM_080823

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~54 kDa

Gene Aliases :SRM, C20orf148, dJ697K14.1

Scientific Background :SRMS is a Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites that is involved in proliferation or differentiation of keratinocytes in the skin. SRMS functions as a rapid downstream signaling intermediate following calcium-induced differentiation in keratinocytes. SRMS constitutes a new family of non-receptor tyrosine kinases that may be redundant in function (1). SRMS can act either in the membrane or at the nucleus, and may change localization patterns depending on external stimuli.

References :
1. Kohmura N. et.al: "A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption." Mol. Cell. Biol. 14:6915-6925,1994.

Product Sheets (By Lot #) :

I157-3.pdf

Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Cytoplasmic Tyrosine Kinases