HOLIDAY SHIPPING UPDATE: All delivery request will not be processed on Monday, February 17, 2020 as it is BC Family Day. Regular delivery schedule will resume the next business day.
Src I1(S19-901)

Src I1(S19-901)

  • $83.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :SRC kinase inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :179248-59-0

Molecular Formula :C22H19N3O3

Appearance :White solid

Melting Point :243-245oC

Molecular Weight :373.4

Purity :≥98% (TLC; 5% CH3OH in CH2Cl2; Rf=0.43); NMR (Conforms)

Solubilization :Soluble in DMSO (15 mg/ml); Ethanol (nil)

Aliases :6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent, competitive dual site (ATP- and substrate-binding domains) Src and Lck inhibitor (IC50 = 44 and 88 nM respectively). Also inhibits VEGFR2 and c-fms at higher concentrations (IC50 = 0.32 and 30 uM respectively).

References :
1. Tian et al. Biochem. 2001 40:7084

2. J Bain et al. Biochem. J. 2007 408:297

Molecular Structure :

Product Sheets (By Lot #) :

T2257-2.pdf

Research Areas :Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Cytoplasmic Tyrosine Kinases