Splitomicin(S35-904G)

Splitomicin(S35-904G)

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Description :SIRT1 Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :5690-03-09

Molecular Formula :C13H10O2

Appearance :White powder

Molecular Weight :198.2

Purity :>98% (TLC)

Solubilization :May be dissolved in DMSO (>25 mg/ml) or ethanol (>25 mg/ml)

Aliases :1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA1. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome2. Reverses ischemic preconditioning-induced cardioprotection in a mouse model3.

References :
1. A Bedalov et al. Proc. Natl. Acad. Sci. USA 2001 98:15113

2. R Biacsi et al. PLoS Genet. 2008 4(3):e1000017

3. SM Nadtochiy et al. Cardiovasc. Res. 2011 89:643

Molecular Structure :

Product Sheets (By Lot #) :

P3320-36.pdf

Research Areas :Cancer, Cell Cycle, Inflammation