SP-600125(M33-900)

SP-600125(M33-900)

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Description :JNK inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :129-56-6

Molecular Formula :C14H8N2O

Appearance :Yellow powder

Melting Point :290oC

Molecular Weight :110.2

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (22 mg/ml); or Ethanol (2 mg/ml)

Aliases :
1. Anthra [1-9-cd] pyrazol-6(2H)-one

2. 1,9-Pyrazoloanthrone

Storage and Stability :Store as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50=40-90 nM) with >300-fold selectivity against related MAP kinases. Anti-inflammatory activity. Inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable. Active in vivo.

References :
1. BL Bennett et al. Proc. Natl. Acad. Sci. USA. 2001 98:13681

2. M Rahman et al. Brain Res. 2012 1448:117

Molecular Structure :

Product Sheets (By Lot #) :

T2257-13.pdf

Research Areas :Cancer, Inflammation, Cardiovascular Disease, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases