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Alpha-synuclein Protein (S22-30H)

Alpha-synuclein Protein (S22-30H)

  • $105.00


Description :Recombinant full length human Alpha-synuclein was expressed in E. coli cells using an N-terminal His tag.

Species :Human

Tag :HIS tag

Expression System:E.coli

Sequence :Full Length

Genbank Number :NM_000345

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~18 kDa

Gene Aliases :NACP; PARK1; PARK4; PD1

Scientific Background :Alpha-synuclein is a member of the synuclein family which also includes beta- and gamma-synuclein. These proteins are abundantly expressed in the brain and alpha- and beta-synuclein selectively inhibit phospholipase D2 which is a highly conserved protein that is also abundant in neurons, especially presynaptic terminals (1). Alpha-synuclein gene is not a major risk factor in familial Parkinson disease (2). Alpha-synuclein may serve to integrate pre-synaptic signaling and membrane trafficking and Alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease.

References :
1. Giasson, B. I. et.al: Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290: 985-989, 2000.

2. Markopoulou, K. et.al: Greek-American kindred with autosomal dominant, levodopa-responsive Parkinsonism and anticipation. Ann. Neurol. 38: 373-378, 19105.

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Research Areas :Cancer, Neurobiology, Cancer, Neurobiology