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Sirtinol(S35-904B)

Sirtinol(S35-904B)

  • $105.00


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Description :SIRT Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :410536-97-9

Molecular Formula :C26H22N2O2

Appearance :Yellow powder

Molecular Weight :394.5

Purity :>98% (TLC)

Solubilization :May be dissolved in DMSO (35 mg/ml) or ethanol (10 mg /ml)

Aliases :2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :Selective sirtuin inhibitor which does not effect HDAC1, IC50 = 131, 38 and 68 uM for SIRT1, SIRT2 and Sir2P respectively1. Induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells2. Suppresses survivin expression which correlates with decreased viability in HT29 colon cancer cells3. Displays pro-inflammatory effects in adipocytes4.

References :
1. CM Grosinger et al. J. Biol. Chem. 2001 276:38837

2. J Wang et al. Int. J. Oncol. 2012 41:1101

3. YF Hsu et al. Biochim. Biophys. Acta 2012 1820:104

4. QQ Lin et al. Cytokine 2012 60:447

Molecular Structure :

Product Sheets (By Lot #) :

P3320-35.pdf

Research Areas :Cancer, Cell Cycle, Inflammation