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SIRT6 Protein(S40-30EG)

SIRT6 Protein(S40-30EG)

  • $215.00


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Description :Full-length recombinant human SIRT6 was expressed in E. coli cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:E.coli

Sequence :Full Length

Genbank Number :NM_016539

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~66 kDa

Gene Aliases :SIR2L6, Sirtuin 6

Scientific Background :SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD(+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin (1). SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. SIRT6 -/- mouse cells show that SIRT6 promotes resistance to DNA damage and suppresses genomic instability in association with a role in base excision repair (2).

References :
1. Michishita, E. et al: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452: 492-496, 2008.

2. Mostoslavsky, R. et al: Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124: 315-329, 2006.

Product Sheets (By Lot #) :

M358-3.pdf

Research Areas :Cancer, Cell Cycle, Inflammation, Cancer, Inflammation, Cell Cycle