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SETD2 (KMT3A), Active(S343-381G)

SETD2 (KMT3A), Active(S343-381G)

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Description :Recombinant human SETD2 (1425-1717) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1425-1717

Genbank Number :NM_014159

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :61 kDa

Gene Aliases :KMT3A; HBP231; HIF-1; HIP-1; HSPC069; HYPB; p231HBP; SET2

Scientific Background :As a member of the mixed lineage leukemia (MLL) family of histone methyltransferase, SETD2 specifically tri-methylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. The main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation.

References :
1. Li Y, et al: Structural basis for activity regulation of MLL family methyltransferases. Nature. 530(7591):447-52. 2016

2. http://www.uniprot.org/uniprot/Q9BYW2

Product Sheets (By Lot #) :

L2041-10.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology