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SENP8, Active (S538-380H)

SENP8, Active (S538-380H)

  • $226.00


Description :  Recombinant human sentrin-specific protease 8, or SENP8, was expressed in E. coli cells using an N-terminal His tag.

Species : Human

Tag : His tag

Expression System : E.coli

Sequence : 360-end

Genbank Number : NM_145204

Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Activity Assay, Western Blot

Molecular Weight :  23 kDa

Gene Aliases :  DEN1, NEDP1, PRSC2

Scientific Background : SENP8 (Sentrin-specific protease 8) is a cysteine protease belonging to the sentrin-specific protease family and catalyzes two crucial functions in the NEDD8 pathway. It was found that SENP8 is not a SUMO protease but functions on a small ubiquitin-related protein called NEDD8 (1). SENP8 is involved in the processing of full-length NEDD8 to its mature form and NEDD8 deconjugation from targeted proteins such as cullins or p53 (2).

References : 
1. Mikolajczyk, J. et al: Small Ubiquitin-related Modifier (SUMO)-specific Proteases: PROFILING THE SPECIFICITIES AND ACTIVITIES OF HUMAN SENPs. The Journal of Biological Chemistry 282: 26217-26224, 2007.

2. Mendoza, H.M. et al: NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem. 278(28):25637-43, 2003.

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Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder