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SENP2, Active (S532-381H)

SENP2, Active (S532-381H)

  • $226.00


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Description :  Recombinant SENP2 (360-end) was expressed in E. coli cells using an N-terminal His tag.

Species : Human

Tag : His tag

Expression System : E.coli

Sequence : 360-end

Genbank Number : NM_021627

Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Activity Assay, Western Blot

Molecular Weight :  28 kDa

Gene Aliases :  KIAA1331, SMT3IP2, AXAM2

Scientific Background : Sentrin-specific protease 2 (SENP2) is a protease that catalyzes the hydrolysis of an alpha-linked peptide bond of the small ubiquitin-like modifier (SUMO) propeptides leading to the mature form of the proteins and the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted protein. SENP2 plays a role in the formation of adipocytes by desumolyating and promoting CEPBP stabilization (1). SENP2 also binds to Nup153, a nucleoporin that is confined to the nucleoplasmic face of the pore and localization of SENP2 to the pore may spatially restrict the activity of this enzyme (2).

References : 
1. WChung, S.S. et al: Control of adipogenesis by the SUMO-specific protease SENP2. Mol. Cell. Biol. 30:2135-2146, 2010.

2. Hang, J. & Dasso, M: Association of the human SUMO-1 protease SENP2 with the nuclear pore. J. Biol. Chem. 277 (22): 19961–6, 2002.

Product Sheets: (by Lot #):

V2289-11.pdf

Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder