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SC-79 (A16-901)

SC-79 (A16-901)

  • $83.00


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Description :  AKT Activator

CAS Registry Number: 305834-79-1

Molecular Formula : C17H17CIN2O5

Appearance : White powder

Molecular Weight : 364.80

Purity : 98% (TLC); NMR (Conforms)

Solubilization : MMay be dissolved in DMSO (100 mg/ml) or ethanol (40 mg/ml, warm)

Aliases : 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester

Storage and Stability : Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to two months.

Scientific Background : Akt activator. Binds to the pleckstrin homology domain of Akt preventing membrane translocation but activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo.

References : 
1. H Jo et al. Proc. Natl. Acad. Sci. USA 2012 109:10581

Molecular Structure : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Product Sheets (By Lot #):

D3370-6.pdf

Research Areas: AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling,