SBK1, Active(S56-10G)

SBK1, Active(S56-10G)

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Description :Full-length recombinant human SBK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_001024401

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~69 kDa

Gene Aliases :SBK

Scientific Background :SBKI or SH3 domain binding kinase 1 is a novel serine/threonine protein kinase structurally related to a Xenopus gastrula-specific protein kinase, Pk9.7 which possessing a consensus sequence for an SH3-binding domain from developing rat brain and it play an important role in signal-transduction pathways related to the control of brain development (1). SBK1 may predict a broad cellular function, and its dysregulated in certain cancers suggests an involvement of the protein in the pathogenesis of human cancers (2).

References :
1. Wang. P.et.al: Human SBK1 is dysregulated in multiple cancers and promotes survival of ovary cancer SK-OV-3 cells. Mol Biol Rep. 2011 Jun; 38(5):3551-9.

2. Nara.K.et.al: Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. Eur J Biochem. 2001 May;268(9):2642-51

Product Sheets (By Lot #) :

A1148-4.pdf

A1244-3.pdf

Q2438-8.pdf

Q2259-8.pdf

Research Areas :Cancer, Ser/Thr Kinases, Cancer, Ser/Thr Kinases