SB-202190(M39-900B)

SB-202190(M39-900B)

  • $121.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :p38 MAP kinase inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :152121-30-7

Molecular Formula :C20H14N3OF

Appearance :Yellow powder

Melting Point :277-278oC

Molecular Weight :331.4

Purity :>98% (TLC: 10% CH3OH in CH2Cl2, Rf=0.25); NMR (Conforms)

Solubilization :May be dissolved in DMSO (30mg/ml)

Aliases :4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Potent and selective p38 MAP kinase inhibitor acting at the ATP site (1). Selectively inhibits the p38alpha and beta isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38beta2 respectively) (2). Effectively blocks LPS-induced gene expression in monocytes (3). Induces apoptosis (4). Cell permeable.

References :
1. PR Young et al. J. Biol. Chem. 1997 272:12116

2. SP Davies et al. Biochem. J. 2000 351:95

3. CL Manthey et al. J. Leukoc. Biol. 1998 64:409

4. S Nemoto et al. J. Biol. Chem. 1998 273:16415

Molecular Structure :

Product Sheets (By Lot #) :

T2257-65.pdf

Research Areas :Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, p38 Pathway, NfkB Pathway, Apoptosis/Autophagy, Cellular Stress, Angiogenesis, Ser/Thr Kinases